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GLP-1 receptors are distributed throughout the central nervous system, including regions involved in appetite regulation and reward processing

Factors That Slow Down Weekly Weight Loss Progress Dose tolerance and side effects can occasionally slow progress if they prevent consistent medication use

The key findings provide the most reliable timeline for expected results: Week 4: Average weight loss of approximately 1 to 2% of body weight Week 12: Average weight loss of approximately 5 to 6% of body weight Week 20: Average weight loss of approximately 10% of body weight Week 40: Average weight loss of approximately 13 to 14% of body weight Week 68: Average weight loss of approximately 15 to 17% of body weight These are averages, meaning some participants lost more and some lost less